--- title: "Spyre Therapeutics (SYRE) stock: news and investor profile" url: "https://aibio.space/companies/spyre-therapeutics/" publisher: "aibio.space (Biotech Investor Relations News)" summary: "Spyre Therapeutics, Inc. (NASDAQ: SYRE), United States. The directory classifies it as Pharmaceuticals: Major." --- SYRE Spyre Therapeutics, Inc. NASDAQ · United States # Spyre Therapeutics (SYRE) news Top story · Oct 7, 2026 · SEC filing 8-K ## [Spyre Therapeutics signs a material agreement](https://www.sec.gov/Archives/edgar/data/1636282/000162828026065291/syre-20261005.htm) Entry into a Material Definitive Agreement On October 5, 2026, Spyre Therapeutics, Inc. Source: [8-K filed Oct 7, 2026 on SEC EDGAR](https://www.sec.gov/Archives/edgar/data/1636282/000162828026065291/syre-20261005.htm) ## Latest Spyre Therapeutics news We have not published a story on Spyre Therapeutics yet. When there is news, it will appear here. ## Spyre Therapeutics at a glance - **Ticker**: SYRE - **Listing**: NASDAQ - **Country**: United States - **Cash, Jun 30, 2026**: $1.15 billion ### Related companies - [Madrigal Pharmaceuticals](https://aibio.space/companies/madrigal-pharmaceuticals/) NASDAQ: MDGL - [Aoxing Pharmaceutical Company](https://aibio.space/companies/aoxing-pharmaceutical/) OTC: AOXG - [Atara Biotherapeutics](https://aibio.space/companies/atara-biotherapeutics/) NASDAQ: ATRA - [Lipella Pharmaceuticals](https://aibio.space/companies/lipella-pharmaceuticals/) OTC: LIPO - [Biofrontera](https://aibio.space/companies/biofrontera-bfri/) NASDAQ: BFRI - [Parabilis Medicines](https://aibio.space/companies/parabilis-medicines/) NASDAQ: PBLS - [Trevena](https://aibio.space/companies/trevena/) OTC: TRVN - [Protara Therapeutics](https://aibio.space/companies/protara-therapeutics/) NASDAQ: TARA ### Also on NASDAQ - [Benitec Biopharma](https://aibio.space/companies/benitec-biopharma/) BNTC - [Candel Therapeutics](https://aibio.space/companies/candel-therapeutics/) CADL - [Quoin Pharmaceuticals](https://aibio.space/companies/quoin-pharmaceuticals/) QNRX - [Beyond Air](https://aibio.space/companies/beyond-air/) XAIR - [BioCryst Pharmaceuticals](https://aibio.space/companies/biocryst-pharmaceuticals/) BCRX - [Alpha Teknova](https://aibio.space/companies/alpha-teknova/) TKNO ## What Spyre Therapeutics does Spyre Therapeutics is a clinical-stage biotechnology company developing long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. Its pipeline includes extended half-life antibodies targeting α4β7, TL1A and IL-23, which the company develops as monotherapies and as pair-wise combinations. The company describes three strategic pillars: next-generation monotherapies engineered for optimized potency, selectivity and pharmacokinetics; fixed-dose combinations of its engineered antibodies for IBD; and expansion of its anti-TL1A program into additional indications, starting with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. The candidates use Fc domain modifications called YTE substitutions to extend half-life and are formulated as high-concentration, citrate-free products. The company says this could enable quarterly or twice-annual subcutaneous maintenance dosing. The company also describes paradigm-changing IBD combinations of its engineered investigational antibodies, designed to enable superior efficacy, safety and convenience. | Product or program | What it is | Stage | |---|---|---| | SPY001 | Long-acting antibody targeting α4β7 for IBD | | | SPY002 | Long-acting antibody targeting TL1A, expanding into rheumatic diseases | | | SPY003 | Long-acting antibody targeting IL-23 for IBD | | Summarised from the company's [10-K filed Feb 19, 2026](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/syre-20251231.htm). ## Spyre Therapeutics annual financials | Line | FY2025 | FY2024 | |---|---|---| | Revenue | [$0](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | [$0](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | | Net income (loss) | [-$155.2 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | [-$208.0 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | | Cash from operations | [-$169.3 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | [-$157.4 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | | Cash and equivalents | [$85.7 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000096/) | [$89.4 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | | Short-term investments | [$670.8 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000096/) | [$513.7 million](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/) | Latest balance sheet, Jun 30, 2026 (10-Q): cash and equivalents $162.0 million, plus short-term investments of $983.3 million, $1.15 billion in all. Figures as reported to the SEC in XBRL; each one links to its filing. Not adjusted, not investment advice. ## Questions about Spyre Therapeutics What is the ticker symbol of Spyre Therapeutics? Spyre Therapeutics, Inc. trades under the ticker SYRE on NASDAQ. Where is Spyre Therapeutics listed? Spyre Therapeutics, Inc. is listed on NASDAQ. Our directory also records these other listings: DUS:3920; FWB:3920; GETTEX:3920; LS:A3D4LY; LSX:A3D4LY; MUN:3920; SWB:3920; TRADEGATE:3920; XETR:3920. What is the SEC CIK of Spyre Therapeutics? The SEC Central Index Key (CIK) for Spyre Therapeutics, Inc. is 1636282. Its filings are on SEC EDGAR. How many shares does Spyre Therapeutics have outstanding? 88,173,762 shares as of 2026-07-28, per the cover page of its 10-Q filed 2026-08-04. Which country or territory is Spyre Therapeutics listed under? Our directory records Spyre Therapeutics, Inc. under United States. What does Spyre Therapeutics do? Our directory classifies Spyre Therapeutics, Inc. as: Pharmaceuticals: Major. This is a directory classification, not a description of the pipeline. What is the ISIN of Spyre Therapeutics? The ISIN recorded for Spyre Therapeutics, Inc. is US00773J2024. Does aibio.space cover Spyre Therapeutics? aibio.space lists Spyre Therapeutics, Inc. among 2,820 public biotech companies and publishes its news here as stories appear. Where is Spyre Therapeutics incorporated? SEC records list its state or country of incorporation as DE. What does Spyre Therapeutics develop? Spyre Therapeutics is a clinical-stage biotechnology company developing long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. Its pipeline includes extended half-life antibodies targeting α4β7, TL1A and IL-23, which the company develops as monotherapies and as pair-wise combinations. What is SPY001 from Spyre Therapeutics? SPY001: Long-acting antibody targeting α4β7 for IBD What is SPY002 from Spyre Therapeutics? SPY002: Long-acting antibody targeting TL1A, expanding into rheumatic diseases What was Spyre Therapeutics's revenue last year? $0 for the fiscal year ended Dec 31, 2025, as reported to the SEC. Is Spyre Therapeutics profitable? Spyre Therapeutics, Inc. reported a net loss of $155.2 million for the fiscal year ended Dec 31, 2025, and used $169.3 million of cash in operations, per its annual report to the SEC. How much cash does Spyre Therapeutics have? $1.15 billion in cash and short-term investments at Jun 30, 2026, per its 10-Q. ## Investor discussion: Spyre Therapeutics Members talk about Spyre Therapeutics (SYRE). Reader posts, not aibio.space reporting, and not investment advice. Rules 1. **Securities violations are strictly forbidden.** No market manipulation, no pump-and-dump, no false or misleading statements, and no inside information. 2. **Say whether you hold the stock.** Every post states long, short or no position. 3. **No paid or sponsored posts.** Do not post for anyone who pays or rewards you. 4. **No buy or sell calls and no price targets.** 5. **No accusations of crime or fraud against named people** unless you link a court filing or a regulator's release that makes them. 6. **No personal details and no spam.** No links at all for your first 7 days as a member. Posts that break the rules may be deleted without notice, and the account restricted or closed. See the [terms](https://aibio.space/terms/#discussion) and the [privacy policy](https://aibio.space/privacy/#discussion). ## Capital-markets timeline Financings, listing notices, splits, legal actions and other investor events at Spyre Therapeutics, newest first. Each line links the filing it comes from. 1. 2026-10-05 Financings Reported a financing. SEC Form 424B5. [Source](https://www.sec.gov/Archives/edgar/data/1636282/000162828026064924/spyre-424b5.htm) 2. 2026-04-13 Financings Reported a financing. SEC Form 424B5. [Source](https://www.sec.gov/Archives/edgar/data/1636282/000162828026024940/spyre-prelimprosuppwithpfw.htm) 3. 2026-01-12 Financings Reported a financing. SEC Form 8-K (Items 7.01,9.01). [Source](https://www.sec.gov/Archives/edgar/data/1636282/000119312526009894/d28401dex991.htm) 4. 2025-10-14 Financings Reported a financing. SEC Form 424B5. [Source](https://www.sec.gov/Archives/edgar/data/1636282/000119312525237918/d70143d424b5.htm) 5. 2025-03-06 Legal Reported a change of independent auditor. SEC Form 8-K (Items 4.01,9.01). [Source](https://www.sec.gov/Archives/edgar/data/1636282/000119312525048423/d861533d8k.htm) 6. 2024-11-18 Financings Reported a financing. SEC Form 424B5. [Source](https://www.sec.gov/Archives/edgar/data/1636282/000162828024048293/spyretherapeutics-prelimin.htm) 7. 2024-11-18 Legal Said earlier financial statements should no longer be relied on. SEC Form 8-K (Items 4.02,8.01). [Source](https://www.sec.gov/Archives/edgar/data/1636282/000163628224000105/syre-20241118.htm) ## Stock chart Price chart and quote supplied by TradingView, delayed as the exchange requires. It loads only if you choose to show it. Information only, not investment advice. [Open NASDAQ:SYRE on TradingView](https://www.tradingview.com/symbols/NASDAQ-SYRE/). ## SEC filings and registration - **SEC name**: Spyre Therapeutics, Inc. - **CIK**: 1636282 - **Industry (SIC)**: Pharmaceutical Preparations (2834) - **US tickers**: SYRE (Nasdaq) - **State or country of incorporation**: DE - **Fiscal year ends**: December 31 - **Filer category**: Large accelerated filer - **Business address**: 221 CRESCENT STREET, WALTHAM, MA, 02453 - **Phone**: 6176515940 - **Shares outstanding**: 88,173,762 as of 2026-07-28 (10-Q filed 2026-08-04) - **Former names**: Aeglea BioTherapeutics, Inc. ### Recent filings (8-K and 6-K are the company's own announcements) - [8-K](https://www.sec.gov/Archives/edgar/data/1636282/000162828026065291/syre-20261005.htm) filed 2026-10-07 - [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026065249/spyre-final424b5.htm) filed 2026-10-06 - [424B5](https://www.sec.gov/Archives/edgar/data/1636282/000162828026064924/spyre-424b5.htm) filed 2026-10-05 - [8-K](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000113/syre-20260908.htm) filed 2026-09-08 - [8-K](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000105/syre-20260825.htm) filed 2026-08-25 - [8-K](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000098/syre-20260804.htm) filed 2026-08-04 - [10-Q](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000096/syre-20260630.htm) filed 2026-08-04 - [8-K](https://www.sec.gov/Archives/edgar/data/1636282/000163628226000083/syre-20260615.htm) filed 2026-06-15 Source: [SEC EDGAR](https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001636282), retrieved October 23, 2026. Shares outstanding is the cover-page figure from the latest periodic report. The SEC does not publish share prices. ## Listing details Spyre Therapeutics, Inc. is a public biotech or pharmaceutical company listed on NASDAQ under the ticker SYRE, recorded under United States. The directory classifies it as Pharmaceuticals: Major. aibio.space tracks 2,820 public biotech companies worldwide and publishes investor news on them. - **Company**: Spyre Therapeutics, Inc. - **Ticker**: SYRE - **Listing**: NASDAQ - **Country or territory**: United States - **Business scope**: Pharmaceuticals: Major - **ISIN**: US00773J2024 - **Other listed symbols**: DUS:3920; FWB:3920; GETTEX:3920; LS:A3D4LY; LSX:A3D4LY; MUN:3920; SWB:3920; TRADEGATE:3920; XETR:3920 - **Last quote in directory**: 2026-10-21 - **Directory source**: [Listing page](https://www.tradingview.com/symbols/NASDAQ-SYRE/) Listing facts come from our company directory, researched on October 22, 2026. 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Cite as: aibio.space, "Spyre Therapeutics (SYRE) stock: news and investor profile", 2026-10-31, https://aibio.space/companies/spyre-therapeutics/